Tuesday, April 30, 2013

Pyongyang glitters, but rest of NKorea still dark

PYONGYANG, North Korea (AP) ? The heart of this city, once famous for its Dickensian darkness, now pulsates with neon.

Glossy construction downtown has altered the Pyongyang skyline. Inside supermarkets where shopgirls wear French designer labels, people with money can buy Italian wine, Swiss chocolates, kiwifruit imported from New Zealand and fresh-baked croissants. They can get facials, lie in tanning booths, play a round of mini golf or sip cappuccinos and cocktails while listening to classical music.

More than a million people are using cell phones. Computer shops can't keep up with demand for North Korea's locally distributed tablet computer, popularly known here as "iPads." A shiny new cancer institute features a $900,000 X-ray machine imported from Europe.

Pyongyang has long been a city apart from the rest of North Korea, a showcase capital dubbed a "socialist fairyland" by state media.

A year after leader Kim Jong Un promised in a speech to bring an end to the "era of belt-tightening" and economic hardship in North Korea, the gap between the haves and have-nots has only grown with Pyongyang's transformation.

Beyond the main streets of the capital and in the towns and villages beyond, life is grindingly tough. Food is rationed, electricity is a precious commodity and people get around by walking, cycling or hopping into the backs of trucks. Most homes lack running water or plumbing. Health care is free, but aid workers say medicine is in short supply.

And while the differences between the showcase capital and the hardscrabble countryside grow starker, North Koreans feel the effects of authoritarian rule no matter where they live.

It's illegal for them to interact with foreigners without permission. Very few have access to the Internet. They calibrate their words. Most parrot phrases they've heard in state media, still the safest way to answer questions in a country where state security remains tight and terrifying.

___

For decades, North Korea seemed a country trapped in time. Rickety streetcars shuddered past concrete-block apartment buildings with broken window panes and chipped front steps.

But in 2010 and throughout 2011, as then-leader Kim Jong Il was grooming son Kim Jong Un to succeed him, Pyongyang was a city under construction. Scaffolding covered the fronts of buildings across the city. Red banners painted with slogan "At a breath" ? implying breakneck work at a breathless pace ? fluttered from the skeletons of skyscrapers built by soldiers.

Often, the soldiers were scrawny conscripts in thin canvas sneakers, piling bricks onto stretchers or hauling them by hand. In 2011, soldiers working on the Mansudae District complex set up temporary camps along the Taedong River, makeshift shantytowns decorated by red flags. After tearing down the tents, the soldiers built a playground for children where their encampment once stood.

Their work was focused downtown, on Changjon Street, where ramshackle cottages were torn down to make way for department stores, restaurants and high-rise apartments.

Today, the street would not look out of place in Seoul, Shanghai or Singapore. Indeed, many of the goods ? Hershey's Kisses, Coca-Cola and Doritos ? on sale at the new supermarket were imported from China and Singapore.

Changjon Street reflects a change of thinking in North Korea. For years, foreign goods and customs were regarded with suspicion, even as they were secretly coveted, especially by those who had traveled abroad or had family in Japan or China.

Kim Jong Un has addressed their curiosity by importing goods and by quoting his father in saying North Korea is "looking out onto the world" ? a country that must become familiar with international customs even if it continues to prefer its own.

"What is a 'delicatessen'?" one North Korean at the new supermarket asked as a butcher in a white chef's hat sliced tuna for takeaway sashimi beneath a deli sign written in English. Upstairs, baristas were serving Italian espressos and bakers churned out baguettes and white wedding cakes.

English, language of the North's archenemy, is outstripping Russian and Chinese as the foreign language of choice. Over the past six months, a new TV channel, Ryongnamsan, has aired "Finding Nemo," ''The Lion King" and "Madagascar" in English ? the first broadcasts of American cartoons on North Korean state TV.

Kim has not made it significantly easier for North Koreans to travel, channel surf or read travelogues posted online, but he is arranging to bring the Eiffel Tower and Big Ben to them in the form of a miniature world park slated to open later this year.

And Pyongyang now has a parade of fashionistas in eye-popping belted jackets, sparkly barrettes clipped to their hair, fingernails painted with a clear gloss.

At one beauty salon, the rage is for short cuts made popular by singers from the all-girl Moranbong band who have jazzed up North Korea's staid performance scene with their bobbed hair, little black dresses and electric guitars.

"There are so many young women asking to get their hair done like them," hairstylist Chae Cho Yong said.

Around her, a cavernous barber shop was empty. An employee explained that most North Koreans are at weekly propaganda study sessions on Saturdays, the only day of the week foreigners are allowed inside.

___

The most coveted housing in North Korea, where homes and jobs are doled out by the state or the powerful Workers' Party, is an apartment on Changjon Street.

One new resident, Mun Kang Sun, gave The Associated Press a tour of the apartment she and her husband were given in recognition for her work at the Kim Jong Suk Textile Factory.

A framed wedding portrait hangs on the wall above their Western-style bed. There's a washing machine in the bathroom, an IBM computer in the study and a 42-inch widescreen TV.

Mun said she was an orphan who began working in factories at age 16. She earned the title "hero of the republic" after exceeding her work quota by 200 percent for 13 years. She says she accomplished that by dashing around the factory floor operating four or five machines at once.

"When we heard the news that we'd get a nest where we can rest, and we got the key for our apartment and took a look around, we were totally shocked because the house is so nice," her husband, Kim Hyok, told AP. "It's still hard to believe this is my home; it still feels like we're living in a hotel."

Though the apartment has faucets, old habits die hard. The bathtub was still filled with water, a bucket bobbing in the tub, as in countless homes across the country where water is pumped from a well, carried in by hand and used sparingly.

One by one, North Korean buildings are getting upgraded but most are still drafty, the walls poorly insulated. Elevators and heat are rare. North Koreans are accustomed to wearing winter jackets and thermal underwear indoors from October to April.

Power cuts have been less frequent in Pyongyang as electricity-generating capacity has grown, but it's still common for the lights to go out in the middle of dinner. Most people just carry on drinking and eating.

___

Outside Pyongyang, the power grid offers little relief from the darkness. West of the capital in the town of Ryonggang, lights were out as soon as the sun set. At one inn, two women stood chatting quietly in a lobby lit with a candle as a shrill voice from a radio broadcast chortled from loudspeakers nearby.

Even North Korea's second-largest city, Hamhung, has little of the capital's urban feel.

Few private cars ply the streets in the city, which is the industrial heart of the country. Hamhung's bus line is largely limited to one main route through town. Soldiers cram into the backs of trucks powered by wood-burning stoves that send smoke billowing behind them.

Some people live in relative comfort. Kim Jong Jin's farmhouse in Hamhung is simple but spotless, the papered floors clean enough to eat from. Water is piped into a well in the kitchen. Heat comes from the traditional Korean "ondol" system of feeding an underground furnace with wood. Waste is turned into methane gas for cooking.

Electric service is spotty, but the family has a generator, so they're able to watch movies at night on the TV they carefully cover with a frilly lace veil.

That is luxurious living compared to the poverty that is evident in the countryside.

A mother huddles over a child as she sits shivering by the side of the road. Barefoot boys in a village destroyed by summer flooding are dressed in little more than underwear, the splotchy faces and gaunt frames of young soldiers who do not get enough to eat.

Bicycles are piled high with bundles of firewood, sometimes even a dead pig. Old men sit crouched by the side of the road with bike pumps, offering to fix flats. Oxen plod past pulling carts.

Paved highways pocked with potholes radiate from Pyongyang. But beyond these roads in dire need of repair, there are no roads between the denuded mountains, just dirt paths that become dangerously muddy with rainfall and treacherously slippery in winter. Villagers struggle to clear snow with makeshift shovels crafted out of planks of wood.

___

Life in the North Korean countryside would be familiar to South Koreans old enough to recall the poverty in their nation just after the Korean War. Indeed, into the 1970s, North Korea was the richer of the two Koreas.

Now, more than a quarter of North Korean children are stunted from chronic malnutrition, the World Food Program reported last month.

North Korea blames its growing international economic isolation on the U.S., which has led efforts to punish it for developing its nuclear weapons program. But in the capital, the effects of that isolation are less apparent, thanks largely to goods from China, the North's most important ally, and other countries such as Singapore and Indonesia. Shelves are stocked with goods, computer labs filled with PCs, streets crowded with VWs.

While millions can't afford meat or fish, and subsist on a few potatoes or a bowl of cornmeal noodles each day, the well-to-do in Pyongyang with extra sources of income can buy beef, pomegranates and vine-ripened tomatoes.

There's even a growing cosmopolitan vibe. At one European-style restaurant Friday, a young couple on a date sipped cocktails topped off with Maraschino cherries and feasted on pizza, their cellphones rattling beside them from time to time.

___

Follow AP's bureau chief for Pyongyang and Seoul at www.twitter.com/newsjean.

Source: http://news.yahoo.com/pyongyang-glitters-rest-nkorea-still-dark-014946168.html

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Floored Generates Customizable 3D Models For Real Estate Using Kinect-Like Sensors

Floored LogoFloored scans office spaces, apartments and houses using 3D camera technology and proprietary software to build customizable 3D models for real estate purposes. At Disrupt NY 2013, the company launched the platform to create an immersive, interactive and user-friendly experience. Instead of static photos and floor plans, you can move around in real-time, add furniture and easily realize if the space is a good fit. “The marketing in the commercial real estate industry is absolutely abysmal,” co-founder and CEO Dave Eisenberg said in a phone interview before Disrupt. “The two-dimensional floor plan has not evolved in decades.” At first, Eisenberg was interested in 3D capturing and wanted to explore potential real-world applications. That’s when he discovered Matterport, a 3D device to capture interior spaces, and partnered with it to take advantage of Matterport’s existing hardware solutions. “Matterport is a pretty incredible technology company. They incorporated the Kinect into a device they built,” Eisenberg said. “It?s the first point-and-shoot solution to grab a 3D capture of your environment.” Matterport now works with Primesense, which manufactures the sensor inside the Kinect. But Floored had to customize the device to their needs and develop a new software layer on top of Matterport’s existing capabilities. The two companies are tackling different pieces of the puzzle and have different clients in mind. Floored cleans up the data in-house and renders the result in real time for the web and its iPad app. The entire process currently takes 48 to 96 hours. At Disrupt, Floored unveiled its next update, due later this year, with new features, such as the ability to change the lighting conditions in real time. Users will also be able to add furniture using a really simple 3D editing tool. “This is the number one most requested feature set,” Eisenberg said onstage. In addition to the technology achievement, Floored allows for nearly limitless customization possibilities. You can make changes to a space and see how it would look like. For example, Floored turned an empty retail space into a coffee shop. In addition to seeing a place in its current condition, you can see it in a new condition. Floored showed the Disrupt crowd an impressive demo of the top floor of One World Trade Center. You can walk around and enjoy the view just like you will be able to do later this year. The New York-based startup has raised $1 million

Source: http://feedproxy.google.com/~r/Techcrunch/~3/2F4UlO3SrfU/

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Obama and O'Brien Cast Their Versions of D.C. White House Correspondents' Dinner

Both President Barack Obama and Conan O'Brien decided to cast Hollywood versions of D.C. at the White House Correspondents' Dinner this year. Obama's version was directed by Steven Spielberg, O'Brien's starred "Tan Mom" as John Boehner.

With the celebrities having walked the White House Correspondents' Dinner red carpet and the crowd in the Washington Hilton having eaten and schmoozed, it came time for the key parts of the evening: remarks from President Obama and Conan O'Brien. Of particular interest was how the president was going to address the recent bombings in Boston, and, along those same lines, what tone O'Brien will take.

Obama came out swinging with jokes at the ready. One of his opening lines joked about his age: ?I?m not the strapping young Muslim socialist I used to be.? He made light of the frenzy over Michelle Obama's bangs, by explaining his strategy for a second term burst of energy showing a series of pictures with his new hairstyle:

He riffed on topics ranging from his Jay-Z's trip to Cuba ("I?ve got 99 problems and now Jay-Z is one of them") to BuzzFeed ("I remember when Buzzfeed was just something I did at college around 2 a.m.") He even took aim at the much maligned NBC when he talked about how he made only two shots at the Easter Egg Roll: "The executives at NBC asked ?what?s your secret?" But his highlight was a video with Steven Spielberg, about Spielberg's new project: "Obama." Spielberg cast Daniel Day-Lewis as Obama, but in the video shown Obama played Daniel Day-Lewis playing Obama. Tracy Morgan played Joe Biden. Here's that clip:

?

But Obama closed on a more serious note. "These have been some very hard days for too many of our citizens," he said. He also complimented the work of journalists during these days, specifically calling out the Boston Globe and NBC's Pete Williams.

Following Obama Conan O'Brien got his fair share of groans?both in the room and on Twitter?when he took aim at a variety of topics ranging from the Hilton, to dying print media, to Kim Jong-Un. He joked that Arianna Huffington made him watch a 30 second ad before he could say hello to her, and that Matt Drudge wasn't there because he had a "he had a prior commitment to teach a web design class in 1997." There were CNN jokes a plenty, including one about how they ?they replaced the popular Larry King with one of the scheming footman from Downton Abbey.? (That's Piers Morgan, of course.) He explained that the media landscape was like a high school cafeteria with NPR as the table for "kids with peanut allergies." There was also a joke about the time Al Roker soiled himself at the White House.

O'Brien then turned his attention to Republicans, saying that the party refers to Marco Rubio as "our black guy" and joking about Reince Priebus' name. (He was sitting between brothers "Lather Priebus and Repeat Priebus.") He went fairly easy on the president, asking why he was still asking for money, and joking about how old he looks.

Before his final joke he took a moment to address Boston, his hometown, and thank the president for going there, but he ended by casting his version of a dramatized version of the Beltway. There Joe Biden will be played by Bob Barker, Paul Ryan by Mr. Bean, and John Kerry by an Easter Island Head:

O'Brien's performance?in which he talked very loudly into the microphone and occasionally banged a gavel?did not go over entirely well on Twitter.

Note to #WHCD: Maybe we just forget about a "headliner" for the next couple years?

? aarongell (@aarongell) April 28, 2013

Watch Obama's speech here and O'Brien's here.

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Source: http://news.yahoo.com/obama-obrien-cast-versions-d-c-white-house-234708035.html

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Monday, April 29, 2013

'Iron Man 3' rules world, 'Pain & Gain' takes US

This film image released by Paramount Pictures shows, from left, Dwayne Johnson, Anthony Mackie and Mark Wahlberg in a scene from "Pain and Gain." (AP Photo/Paramount Pictures, Jaime Trueblood)

This film image released by Paramount Pictures shows, from left, Dwayne Johnson, Anthony Mackie and Mark Wahlberg in a scene from "Pain and Gain." (AP Photo/Paramount Pictures, Jaime Trueblood)

(AP) ? "Iron Man 3" is the heavy-lifter at theaters with a colossal overseas debut that overshadows a sleepy pre-summer weekend at the domestic box office.

The superhero sequel starring Robert Downey Jr. got a head-start on its domestic launch next Friday with a $195.3 million opening in 42 overseas markets.

Sunday studio estimates show director Michael Bay's true-crime tale "Pain & Gain" muscled into first-place domestically with a $20 million debut.

The movie starring Mark Wahlberg, Dwayne Johnson and Anthony Mackie knocked off Tom Cruise's sci-fi adventure "Oblivion" after a week in the No. 1 spot. "Oblivion" slipped to second-place with $17.4 million, raising its domestic total to $64.7 million.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-28-US-Box-Office/id-1928f604bc1f439e83aa2bec3cfe65cc

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Most Expensive (and Unique) Ballpark Foods In America | Bleacher Report

Bleacher Report:

One thing that's true about most sports fans is that they'd rather go to a game than watch it on TV.

The following slides show some of the best and most unique stadium items in American sports?and they just so happen to be very expensive.

Read the whole story at Bleacher Report

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Source: http://www.huffingtonpost.com/2013/04/27/most-expensive-and-unique_n_3171743.html

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Sunday, April 28, 2013

Pat Healy submits Jim Miller at UFC 159, but Bruce Buffer almost announces wrong winner

Jim Miller is 5-foot-8, fights at 155 lbs., and has a bushy red beard. Pat Healy is 5-foot-9, fights at 155 lbs., and sported a trimmed red beard at UFC 159. Can you blame UFC announcer Bruce Buffer for mixing them up?

Healy, who returned to the UFC after spending much of his career in Strikeforce, put Miller to sleep with a rear naked choke in the third round of their thrilling bout. As the two stood on either side of referee Herb Dean to have the fight result announced, Buffer announced the winner by submission was Jim Mill-Pat Healy!

Healy smiled and corrected Buffer, who rarely makes such errors. It was a lighthearted moment that Healy laughed about after a thrilling bout.

Miller started out landing leg kicks and used ground and pound to beat up Healy in the first round. Near the end of the round, Healy was saved by the bell as Miller's ground and pound was close to ending the bout before the horn sounded.

[Also: Two bizarre endings mar UFC 159 prelims]

It was in the third that Healy turned the bout around. Healy weakened Miller with striking, then took him down and took his back. He sunk in the rear naked choke, and Miller's arms went limp. The fight was stopped at 4:02 in the third because Miller was out.

Miller wanted to use the bout to convince UFC president Dana White that he was ready for a title shot. Instead, it was Healy who stood out. In his post-fight interview with UFC commentator, he warned other UFC lightweights to watch out because he was "putting them on blast."

Other popular content on Yahoo! Sports:
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Source: http://sports.yahoo.com/blogs/mma-cagewriter/pat-healy-submits-jim-miller-ufc-159-bruce-030349579.html

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FAA suspends employee furloughs, bill held up by typos

David Goldman / AP

A passenger sits at right in the international terminal at Hartsfield-Jackson airport, Friday, April 26, 2013, in Atlanta.

By Matthew DeLuca, Staff Writer, NBC News

The Federal Aviation Administration will suspend all employee furloughs and return air traffic facilities to their regular staffing levels by Sunday evening, according to a statement released on Saturday.

Travelers across the nation faced delays while the FAA grappled with cuts to air traffic controllers this week forced by the sequester, the $85 billion in automatic spending cuts that took effect on March 1.

The FAA was forced to furlough 13,000 air traffic controllers among its 47,000 employees.

A bill to give the FAA flexibility in defraying its spending cuts was passed by the House of Representatives on Friday. White House press secretary Jay Carney said on Friday that President Obama would sign the legislation when it arrives on his desk.

A few typos have delayed the delivery of the bill to the president for a day or two, however, NBC News? Chuck Todd reported on Saturday. The president may not sign the bill until Monday.

Related:

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Saturday, April 27, 2013

Boston suspects had 'spontaneous' bomb plan for NYC

By Edith Honan and Mark Hosenball

NEW YORK/WASHINGTON (Reuters) - The two brothers suspected of carrying out last week's deadly Boston Marathon bombing decided, after the FBI released photos of them, to drive to Manhattan and detonate more explosives in Times Square, New York City officials said on Thursday.

Their plan unraveled when they realized a Mercedes sport utility vehicle they had hijacked on April 18, three days after the Boston bombing, did not have enough gasoline for the journey, said New York Police Commissioner Ray Kelly.

New York has been on heightened alert since the September 11, plane hijackings in 2001 destroyed the World Trade Center and officials said the plan by the Boston bombing suspects, ethnic Chechens Tamerlan and Dzhokhar Tsarnaev, showed America's most populous city remained a magnet for attackers.

Manhattan's Times Square was the target of an attempted car bombing by a Pakistan-born U.S. citizen in May 2010.

In the sharpest criticism of President Barack Obama's security policies since the blasts, a Republican senator said the Boston bombing, which killed three people and wounded 264, illustrated a "broken" national security system.

This week, lawmakers demanded answers about what the U.S. government knew about the suspects before the bombing, especially Tamerlan Tsarnaev, 26, who Russia had asked the FBI to question in 2011 over concerns he may have been a radical Islamist. He died on Friday in a shootout with police.

The surviving brother, 19-year-old Dzhokhar Tsarnaev, is recovering from wounds in a Boston hospital since he was captured on Friday night and told investigators of the alleged Times Square plan.

"Questioning of Dzhokhar revealed that he and his brother decided spontaneously on Times Square as a target," Kelly told a news conference with New York Mayor Michael Bloomberg. "They would drive to Times Square that same night.

"That plan, however, fell apart when they realized that the vehicle that they hijacked was low on gas and ordered the driver to stop at a nearby gas station," Kelly said.

At the time, the men still had six explosive devices, including a pressure-cooker bomb of the type used at the marathon and six pipe bombs, he said.

When they stopped to refuel, the driver of the vehicle escaped, Kelly said. The driver alerted authorities and set off a late-night chase and shootout in suburban Watertown, where police say the suspects threw improvised explosives at officers. Hours earlier, the brothers had shot and killed a Massachusetts Institute of Technology campus police officer in Cambridge, authorities said.

Earlier on April 18, the FBI released photos and video of the at the scene of the Boston bombing.

One Republican congressman said investigators have identified "persons of interest" in the United States to whom they would like to speak, some of them because of calls made from Tamerlan Tsarnaev's cell phone.

"There are also persons of interest here that we would like to more fully understand," said Mike Rogers, the chairman of the House of Representatives Intelligence Committee. "Their relationship and what role, if any, they may have played in that whole radicalization process. They are just still persons of interest, so they are not named."

Rogers also said investigators want to learn more about Tamerlan Tsarnaev's 2012 visit to Russia.

PARENTS SAY SONS INNOCENT

Dzhokhar Tsarnaev was formally charged on Monday in the hospital with crimes that could carry the death penalty.

His lawyer, Miriam Conrad, declined to comment on whether her client was still talking with investigators.

The U.S. Marshals Service, which is responsible for holding and transporting suspects outside of prison, declined to comment on whether or when Tsarnaev might be moved from the Beth Israel Deaconess Medical Center.

The brothers' father said he planned to travel to the United States from Russia to bury his older son, Tamerlan Tsarnaev.

"I am going to the United States. I want to say that I am going there to see my son, to bury the older one. I don't have any bad intentions. I don't plan to blow up anything," Anzor Tsarnaev told reporters in Makhachkala, the capital of Russia's Dagestan region.

Massachusetts Governor Deval Patrick said investigators might be interested in speaking to the parents.

"There are a lot of questions unanswered about the whys and the hows, and anybody who may be able to shed some light on that is of interest to law enforcement," Patrick said.

Anzor Tsarnaev's former wife, Zubeidat Tsarnaeva, angrily denied that her son had any role in the attack and criticized police for shooting him while apprehending him.

Tsarnaeva does not plan to accompany her former husband on his trip. One factor that may have influenced her decision is an outstanding arrest warrant for her in Massachusetts.

A warrant for Zubeidat Tsarnaeva's arrest was issued on October 25 after she failed to make a court appearance on shoplifting-related charges, according to Natick District Court Clerk Brian Kearney.

'WITCH HUNT'

In Washington, the focus remained on intelligence leading up to the Boston Marathon bombing. Tamerlan Tsarnaev had been on a federal database of potential terrorism suspects and the United States had twice been warned about him by Russian authorities. Congressional testimony this week focused on whether the FBI made mistakes in tracking him.

"We're in the post-event witch-hunt phase, which is predictable," said James Clapper, director of national intelligence, at a conference in Crystal City, Virginia. "I think it would be a real good idea to not hyperventilate for a while now until we actually get all the facts."

Nonetheless, Republican Senator Lindsey Graham blamed the administration for failing to stop the attack.

"I just know the system is broken. The ultimate blame I think is with the administration," the South Carolina senator told reporters, linking the bombings with last year's killing of a U.S. diplomat during an attack on a diplomatic compound in Benghazi, Libya.

"Between Benghazi and Boston, to me we're going backwards, not forward, in terms of national security," Graham said.

(Additional reporting by Tim McLaughlin, Svea Herbst-Bayliss, Aaron Pressman, Ross Kerber in Boston, Deborah Charles in Crystal City, Virginia, Alissa de Carbonnel in Makhachkala, Russia, and Atossa Araxia Abrahamian in New York; Writing by Scott Malone and Alex Dobuzinskis; Editing by Paul Thomasch, Mary Milliken and Christopher Wilson)

Source: http://news.yahoo.com/boston-suspects-had-spontaneous-bomb-plan-york-013726316--sector.html

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Congressman questions legal handling of Boston suspect

By Tabassum Zakaria

WASHINGTON (Reuters) - U.S. House Intelligence Committee Chairman Mike Rogers has expressed concern to Attorney General Eric Holder that the legal handling of the Boston Marathon bombing suspect may have "prematurely cut off" a lawful FBI interview.

Rogers, a Republican from Michigan, said he wanted more information about the appearance by U.S. Magistrate Judge Marianne Bowler at the hospital where Dzhokhar Tsarnaev is being held after being charged in the bombings that killed three people and wounded more than 200.

"Specifically, I would like more information as to who determined that the proceedings would occur at that specific time and place while questioning was still ongoing," Rogers said in a letter dated Wednesday and obtained by Reuters on Thursday.

"My understanding is that the normal practice places the duty to take the defendant to court (and accordingly discretion as to timing consistent with the rules) on law enforcement, and not the court," the letter said.

Tsarnaev, who was captured on Friday, was charged at a bedside hearing on Monday with using a weapon of mass destruction and malicious destruction of property resulting in death. He and his older brother, Tamerlan, who was killed in a shootout with police, are both suspected with carrying out the Boston Marathon bombings.

It was during the proceeding before Bowler that Tsarnaev was warned of his right to remain silent and his right to an attorney.

Before Monday's hearing, Dzhokhar Tsarnaev told investigators that he and his brother had also planned to set off bombs in New York's Times Square, according to Police Commissioner Ray Kelly.

There is an ongoing debate about whether authorities should hold off reading the so-called Miranda warning to a suspect in a terrorism case until questioning has been completed to ensure no other plot is in the works that could harm the public.

A federal law enforcement official told Reuters that the magistrate judge initiated the process.

"The court schedules initial court appearances for defendants, not the Justice Department," the official said.

Federal Rules of Criminal Procedure require that anyone who is arrested must appear before a magistrate judge "without unnecessary delay" and that, during the proceeding, the magistrate judge must advise the defendant of his or her right to remain silent.

After the criminal complaint was filed on Sunday, Bowler sought to arrange an appearance for Monday morning, according to the law enforcement official. Prosecutors, the federal public defender and FBI agents in Boston were all aware of Bowler's plans, the official said.

(Additional reporting by Lawrence Hurley; editing by Karey Van Hall and Christopher Wilson)

Source: http://news.yahoo.com/congressman-questions-legal-handling-boston-suspect-231858887.html

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North Korea rejects Seoul deadline for talks

SEOUL, South Korea (AP) ? North Korea on Friday rejected a South Korean demand for talks on a jointly run factory park that has been closed nearly a month and said Seoul was free to withdraw its remaining citizens from the industrial complex if it wanted.

A day earlier, Seoul had threatened unspecified "grave measures" in setting a Friday deadline for Pyongyang to respond to its call for working-level discussions of the fate of the Kaesong industrial complex. Pyongyang's powerful National Defense Commission batted that threat back in a statement with its own warning of "grave measures."

While neither capital is providing specifics about what those measures might be, the war of words calls into question the future of the last major symbol of inter-Korean cooperation.

The park in the North Korean border town of Kaesong is the most significant casualty so far in the recent deterioration of relations between the Koreas. Pyongyang barred South Korean managers and cargo from entering North Korea early this month, then recalled the 53,000 North Koreans who worked on the assembly lines.

Seoul said it set a Friday deadline for Pyongyang to respond to the call for talks because the roughly 175 workers remaining at Kaesong are running short of food and medicine.

An unidentified spokesman for the National Defense Commission said in a statement carried by state media Friday that Seoul's demand for working-level talks was deceptive and said similar demands would "only speed up final destruction" of South Korea.

"If they are truly worried about the lives of South Korean personnel in the (complex), they may withdraw all of them to the south side where there are stockpiles of food and raw materials and sound medical conditions," the statement said, adding that North Korea would guarantee their personal safety during the withdrawal.

"If the South's puppet group looks away from reality and pursues the worsening of the situation, we will be compelled to first take final and decisive grave measures," the statement said.

The dueling statements on Kaesong this week follow what had been something of a lull after a weeks-long tirade of warlike North Korean rhetoric that included threats of nuclear war and missile strikes. Tension rose as Seoul responded with its own tough language to Pyongyang's outburst, which was unusually violent, even by the standards of the already hostile relationship between the Koreas.

The rhetoric from Pyongyang was seen by some analysts as an attempt to try to force Pyongyang-friendly policies in Seoul and Washington. Pyongyang has expressed some tentative signs of interest in dialogue, though its demands, including dismantling all U.S. nuclear weapons, go far beyond what its adversaries will accept.

One analyst said the North's response Friday was an effort to salvage its pride.

"North Korea is afraid of losing face by allowing South Korea to be assertive and take the lead in their relations," Hwang Jihwan, a North Korea expert at the University of Seoul, said Friday. "The North Koreans want a concession from South Korea so they can also step back and look generous."

South Korea said Friday it was considering countermeasures but refused to discuss what they might be. South Korean President Park Geun-hye held a meeting Friday with officials focusing on Kaesong, and her minister in charge of inter-Korean matters planned a statement on the complex later in the day.

Park was quoted as saying during the meeting that her government "asked that North Korea allow at least basic humanitarian things like medicine and food, but with this refusal, damage to our companies, people and families is growing. The best way would be to normalize the Kaesong industrial complex, but (I wonder) if (we) should wait indefinitely. Our people are sacrificing too much." She didn't elaborate, according to an initial pool report from the presidential Blue House.

Some observers said Seoul's threat Thursday of "grave measures" may signal a willingness to pull out its managers from the complex.

Meanwhile, the military drills continue. On Friday, airplanes flew over South Korea's southeastern city of Pohang and amphibious vessels landed on the coast. North Korea calls the drills, which are set to end Tuesday, war preparations.

"Even at this moment, South Korea is ramping up the intensity of coastal landing drills with the United States in the east, driving the already tense situation to a point of explosion," North Korea said in its statement. It said the annual drills and the scattering of North Korean leaflets along the border belie the South Korean government's calls for talks.

The Kaesong complex has operated with South Korean know-how and technology and with cheap labor from North Korea since 2004. It weathered past cycles of hostility between the rivals, including two attacks blamed on North Korea in 2010 that killed 50 South Koreans.

Unification Ministry spokesman Kim Hyung-suk, speaking ahead of North Korea's statement, said Friday that Seoul would "take appropriate measures at an appropriate time" but would not elaborate. He said South Korea wants to restore normal operations at Kaesong.

Impoverished North Korea objects to views in South Korea that the park is a source of badly needed hard currency. South Korean companies paid salaries to North Korean workers averaging $127 a month, according to South Korea's government. That is less than one-sixteenth of the average salary of South Korean manufacturer workers.

Pyongyang also has complained about alleged South Korean military plans in the event the North held the Kaesong managers hostage.

Source: http://news.yahoo.com/north-korea-rejects-seoul-deadline-talks-100502807.html

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Friday, April 26, 2013

AT&T to sell home automation, security packages

NEW YORK (AP) ? AT&T Inc. is launching its home security and automation service in 15 cities Friday, with an eye toward getting customers hooked on security cameras, thermostats and locks they can control from phones and tablets.

AT&T's "Digital Life" packages will be sold in cellphone stores in markets including Los Angeles, Chicago, San Francisco and Miami. The company plans to roll the offering out to 50 markets by the end of the year.

The home monitoring and automation field is dominated by security firms such as ADT Corp. Other phone and cable companies sell security packages, but AT&T is going further than competitors by developing its own technology and selling it nationwide, not just where it provides local phone service. It has set up monitoring centers, in Dallas and Atlanta.

The entire U.S. home security market is worth about $18 billion per year, said Glenn Lurie, who is in charge of expanding the reach of AT&T's network to new types of devices. That's small compared to AT&T's $127 billion in annual revenue. But only 20 percent of homes have security systems, so there's an opportunity to expand the market, Lurie said.

The initiative comes as the wireless industry has slowed after a decade of heady growth. Now that nearly everyone has a cellphone, wireless companies are looking for other sources of growth.

"We see huge opportunity here. This is a significant, billion-dollar opportunity for AT&T," Lurie said.

AT&T is also hoping to get customers to pay more than the typical $40 per month for home security alone, by providing connections to wireless cameras and other sensors.

AT&T will charge $250 for the equipment and installation of a home security package, plus $40 per month. Options include a camera package for $10 per month plus equipment and installation, climate control for $5 per month, and a remote water main shutoff control for $10 per month.

The equipment ties into a central control panel which can be programmed through the app or Web interface to, for instance, shut off the water main if the water sensor detects a leak.

A basic, security-only package will cost $150, plus $30 per month.

Ralph De La Vega, head of AT&T's wireless division, said employees who tested Digital Life in Atlanta and Dallas last year bought a lot more cameras than the company had been expecting. One of them set a camera to be triggered by motion sensor on the front porch, and nabbed a thief who had been stealing packages.

Only about 1 percent of homes have automation systems, and De La Vega said this could be a big opportunity as well. He's happy he can now check whether his garage doors are open and close them from his phone.

"It's just getting people used to living a different way ... We haven't even begun to tap into the available marketplace. I think the idea is huge," De La Vega said.

The central panel connects to AT&T's wireless network, but should also be connected to a wired Internet modem for redundancy, AT&T said. Any Internet connection will work ? it doesn't have to be AT&T's.

Two years ago, AT&T bought Xanboo, a smart-home technology startup. Last year, AT&T announced its plans to launch Digital Life nationwide, and ran trials with employees in Dallas and Atlanta.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-26-APFN-US-TEC-ATandT-Smart-Home/id-fd1e1dc4396447ec8e76b77fe8466189

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Pushing the boundaries of transcription

Friday, April 26, 2013

Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings, published today in Nature, shed new light on the importance of mRNA boundaries in determining the functional potential of genes.

Hundreds of thousands of unique mRNA transcripts are generated from a genome of only about 8000 genes, even with the same genome sequence and environmental condition. "We knew that transcription could lead to a certain amount of diversity, but we were not expecting it to be so vast," explains Lars Steinmetz, who led the project. "Based on this diversity, we would expect that no yeast cell has the same set of messenger RNA molecules as its neighbour."

The traditional understanding of transcription was that mRNA boundaries were relatively fixed. While it has long been known that certain parts of mRNAs can be selectively 'spliced' out, this phenomenon is very rare in baker's yeast, meaning that the textbook one gene - one mRNA transcript relationship should hold. Recent studies have suggested that things aren't quite that simple, inspiring the EMBL scientists to create a new technique to capture both the start and end points of single mRNA molecules. They now discovered that each gene could be transcribed into dozens or even hundreds of unique mRNA molecules, each with different boundaries.

This suggests that not only transcript abundance, but also transcript boundaries should be considered when assessing gene function. Altering the boundaries of mRNA molecules can affect how long they stay intact, cause them to produce different proteins, or direct them or their protein products to different locations, which can have a profound biological impact. Diversifying mRNA transcript boundaries within a group of cells, therefore, could equip them to adapt to different external challenges.

The researchers expect that such an extent of boundary variation will also be found in more complex organisms, including humans, where some examples are already known to affect key biological functions. The technology to measure these variations across the entire genome as well as a catalogue of boundaries in a well-studied organism are a good starting point for further research. "Now that we are aware of how much diversity there is, we can start to figure out what factors control it," points out Vicent Pelechano, who performed the study with Wu Wei. Wei adds: "Our technique also exposed new mRNAs that other techniques could not distinguish. It will be exciting to investigate how these and general variation in transcript boundaries actually extend the functional capacity of a genome."

###

European Molecular Biology Laboratory: http://www.embl.org

Thanks to European Molecular Biology Laboratory for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 35 time(s).

Source: http://www.labspaces.net/127960/Pushing_the_boundaries_of_transcription

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Women's Health Forum Preview- Weight Loss Champion | KTLA 5

Gayle Anderson was live in Lawndale to begin her contribution to the KTLA morning news ?Lose 5 With 5? month long health and fitness initiative. As part of this program, each Fitness Syndicate member was given one week with the contestants to train them for two to three days on various methods of fitness training.

Admission to the Women?s Health Forum is FREE, although you must register online by clicking HERE.?West Hall parking at the Los Angeles Convention Center is $12. For more information, call (310) 330-2235.?

13th Annual KJLH Women?s Health Forum
Saturday, April 27, 2013
Check-in begins at 7:00 a.m.?
8 a.m. to 3 p.m.?
Admission is FREE
Los Angeles Convention Center
1201 South Figueroa Street
Los Angeles, CA 90015
(310) 330-2235

If you want to follow Gayle?s ?Lose Five with Five? progress, you can contact Gayle via:
Twitter: @ KTLAGayle
Facebook: Gayle Anderson

If you have questions, please feel free to call Gayle Anderson at?323-460-5732?or e-mail Gayle at?Gayle.Anderson@KTLA.com.

Source: http://ktla.com/2013/04/24/womens-health-forum-weight-loss-champion/

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What Was Boston Bombing Suspect Doing in Dagestan? (Voice Of America)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301608362?client_source=feed&format=rss

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Thursday, April 25, 2013

Syrian army seizes strategic town near capital

By Mariam Karouny and Erika Solomon

BEIRUT (Reuters) - Syrian forces loyal to President Bashar al-Assad seized a strategic town east of Damascus on Wednesday, breaking a critical weapons supply route for the rebels, activists and fighters said.

Rebels have held several suburbs ringing the southern and eastern parts Damascus for months, but they have been struggling to maintain their positions against a ground offensive backed by fierce army shelling and air strikes in recent weeks.

"The disaster has struck, the army entered Otaiba. The regime has managed to turn off the weapons tap," a fighter from the town told Reuters via Skype.

"The price of a bullet will go from 50 Syrian pounds to 1,000 Syrian pounds ($10) now, but we must pay and retake it. It's the main if not the only route."

Rebels said they pulled out of Otaiba, a gateway to the eastern rural suburbs of Damascus known as al-Ghouta, in the early hours after more than 37 days of fighting in which they accused the government of using chemical weapons against them twice.

The government has denied using chemical weapons and accused rebels in turn of firing them in Aleppo.

Rebels used Otaiba for eight months as their main supply route to Damascus for weapons brought in from the Jordanian border, where Saudi Arabia and other private donors are believed to be sending in arms.

Government forces pushed in with tanks and soldiers.

"Now all the villages will start falling one after another, the battle in Eastern Ghouta will be a war of attrition," another fighter in the area said, speaking by Skype.

More than two years into their struggle to end four decades of Assad family rule, the rebels remain divided by struggles over ideology and fighting for power

Rebels fighting in Otaiba said they sent a distress call to brigades in other parts of Ghouta but it went unanswered by other units with whom they compete for influence and weapons.

"To all mujahedeen (holy warriors): If Otaiba falls, the whole of Eastern Ghouta will fall ... come and help ," part of the message sent to fighters said.

The army appears to have been advancing on fronts across Syria in recent weeks, even in northern provinces where rebels seized large swathes of territory.

MINARET COLLAPSES

Most critically, it has made gains around Damascus and the Lebanese-Syrian border - critical to linking the capital to coastal provinces that are Assad's stronghold.

The coast is an enclave of Assad's minority Alawite sect, an offshoot of Shi'ite Islam. Alawites have dominated Syria's power structures during four decades of Assad family rule.

Rebels, mostly from the Sunni Muslim majority, have seized territory in northern and southern Syria, and hold about half of Aleppo, the country's biggest city. But Assad's forces have kept control of the capital Damascus and most major cities.

Elsewhere in Damascus, two mortar bombs hit the government-held suburb of Jaramana, killing seven and wounding more than 25, activists and state media said. State news agency SANA blamed the attack on "terrorists", the term it commonly uses to describe Assad's armed opponents.

Some rebel units condemned the attack on Jaramana.

"Our brigade loudly condemns these criminal acts, which have nothing to do with Islam in any way," the Saad bin Abada al-Khudraji brigade said.

Islamist rebel units said on Wednesday they had launched an offensive on the coastal province of Latakia, a move which could further stoke sectarian tensions in a war that has increasingly divided the country along religious and ethnic lines.

Islamist fighters said they had fired two rockets that hit the town of Qurdaha, the birthplace and burial site of Assad's father, Hafez al-Assad, who ruled Syria for 30 years. Residents in Latakia province who spoke to Reuters by Skype said the rockets hit outside Qurdaha, in a rural area called Slunfeh.

It is impossible to verify the account due to government restrictions on media access in Syria.

Moscow was flying more Russians home after delivering humanitarian aid to Latakia, the Emergencies Ministry said. It was one of several government flights laid on in the past months by Russia, a long-standing arms supplier to Damascus.

The conflict has cost more than 70,000 lives and has also damaged or destroyed many archaeological and architectural treasures, some of them U.N. world heritage sites, such as Aleppo's Old City where the mosque is located.

The 1,000-year-old minaret of Aleppo's Umayyad Mosque has collapsed due to clashes between Syrian rebels and Assad's forces, activists and state media said on Wednesday.

The opposing parties blamed the other for the toppling of the minaret, which predated the medieval-era mosque it stood in. Fighting has ravaged the Old City's stone-vaulted alleyways for months and had already reduced much of the mosque to rubble.

SANA accused the Nusra Front, an al Qaeda-linked rebel group, of bringing down the minaret. Opposition groups said army tank fire was to blame.

(Editing by Alison Williams)

Source: http://news.yahoo.com/mortar-attack-hits-government-held-suburb-damascus-132539752.html

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Wednesday, April 24, 2013

Kiefer Sutherland Reluctant Fundamentalist Interview

kiefer

Mira Nair?s film of the novel ?The Reluctant Fundamentalist? isn?t about terrorism, Kiefer Sutherland observes, but about the reaction to terrorism ? a very different thing.

?It?s what I was moved by when I read the material,? Sutherland, 46, says, relaxing in a conference room of a Union Square hotel in Manhattan. ?My focus on 9/11 was on the victims ? in the towers, in the planes ? and all that loss.

?But I didn?t think of the profound ripple effect it had on people of the Muslim faith, on people of color ? of the effect it had on them here and abroad. This script made me focus on the reaction ? from suspending our own civil liberties to being able to get through that initial anger and deal with the specific problem, as opposed to just lashing out.?

In the film, Riz Ahmed plays Changez Khan, a Pakistani who goes to Princeton and rises quickly to become a Wall Street analyst, who is hired by Sutherland, as the head of a firm who spots Changez as a young man with a future. But that future starts to crumble after the events of Sept. 11, 2001, which doesn?t necessarily radicalize Changez so much as alter the way he is perceived in the U.S.

?I love the character Riz plays,? Sutherland notes. ?He understands, he empathizes ? hey, the kid is living the American dream. But if you keep telling someone that they?re something ? even if they?re not that thing ? eventually they?ll become that thing. In our reaction to 9/11, I think we alienated a lot of people who could have helped us deal with the real problem.

?When I read the script, I was really moved by it. I found the script unbelievably enlightening. I hope people who see the movie are as moved by it as I was by the material. Ideologically, it represented how I felt.?

It seems ironic to Sutherland, who spent 2001-10 starring on the counter-terrorism thriller ?24? on TV, that no one so far in interviews has mentioned the show ? with its explicit and melodramatic use of torture as a regular plot device. But Sutherland is ready when it is mentioned.

?My response is simple: For starters, we were shooting the first season of ?24? six months before 9/11 happened,? he says. ?And ?24? was born out of a fantasy. We were trying to create a new format with which to tell a story. The torture sequences were a great dramatic device that gave the show a sense of urgency and dynamics. Whereas this film is a response to a reality. To me, the difference is night and day.?

Sutherland notes that a lot of reaction and opinions about terrorism following 9/11 were ?born out of ignorance. That leads to prejudice and racism. It?s too easy to issue a blanket indictment of a group of people. If you take a minute to learn about the situation before you form an opinion, it helps. But that?s something we do ? myself included.?

Since the end of ?24,? for which he won both an Emmy and a Golden Globe, Sutherland has been working relatively steadily, doing a revival of ?That Championship Season? on Broadway and, most recently, in the two seasons of the series ?Touch.? While that show doesn?t look like it will be back for a third season, Sutherland says, ?I had a great time. I really enjoyed the second season. I loved the pilot script and just decided that I?d rather do it than regret not doing it. I also like working. I seem to do better when I?m working than when I?m not.?

Currently filming ?Pompeii? for director Paul W.S. Anderson, Sutherland also hopes to finally make a film with his father, Donald Sutherland, a western they plan to shoot in Calgary in August.

?It?s the first time we?re working together,? Sutherland says. ?It?s one of those one-shot deals, where you want to find something that is going to be special. When Jane and Henry Fonda finally worked together, it was ?On Golden Pond.? You only get to do something like this once.?

He?d also like to do more theater, and has a particular interest in finding a new play to work on.

?I guess that?s partly my fault ? I might not be on top of anybody?s list, when it comes to access to new material,? he says. ?So I do revivals of ?The Glass Menagerie? (which he did in Canada with mother Shirley Douglas) and ?That Championship Season.? What I?d like to do now is find a new play I was excited about.?

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Source: http://www.rottentomatoes.com/m/1927329/news/1927329/

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Forget styluses! Use a Sharpie on your capacitive touchscreen tablet!

Here’s a stylus that will turn heads. ?Instead of those short, skinny styluses that cause your fingers to cramp up, add a Stylus Cap from More/Real to your Sharpie. ?Sharpies are a good size to hold comfortably, and the added stylus cap means you’ll be able to use it with your tablet or smart phone [...]

Source: http://the-gadgeteer.com/2013/04/24/forget-styluses-use-a-sharpie-on-your-capacitive-touchscreen-tablet/

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Putin foe Navalny urges Russian court to throw out charges

By Gabriela Baczynska

KIROV, Russia (Reuters) - Russian protest leader Alexei Navalny urged a court on Wednesday to throw out what he said were trumped-up charges intended to silence one of President Vladimir Putin's sharpest critics.

A court in the industrial city of Kirov adjourned to consider his request to return the case to state prosecutors for review on day two of his trial on charges of stealing from a timber firm that carry a possible 10-year jail term.

The most prominent opposition leader to be tried in post-Soviet Russia, Navalny, 36, has suggested Putin ordered the trial to stop his criticism of "swindlers and thieves" in government and sideline him as a potential presidential rival.

A recent opinion poll indicated about 37 percent of Russians know who Navalny is, a sharp increase in the past two years, but only 14 percent would vote for him in a presidential election. Putin won almost two-thirds of votes in an election last year.

"The case absolutely cannot be tried in court in its current form," the anti-corruption campaigner told reporters after Judge Sergei Blinov ordered a more than three-hour recess to consider his plea to send the case back to state prosecutors.

"It's raw, it's tendentious, there are different numbers cited everywhere, different amounts of timber are mentioned, and so on," Navalny said, adding that he was surprised the judge had agreed to consider the defense appeal.

Navalny, in jeans and a blue shirt, sat taking notes at the front of the court as the judge spoke. At times he turned to consult his wife Yulia who sat behind him in the packed courtroom in Kirov, about 550 miles northeast of Moscow.

Navalny, who organized the biggest protests since Putin rose to power 13 years ago, is accused of stealing 16 million roubles ($510,000) from a timber firm in Kirov that he was advising in 2009 while working for the liberal regional governor.

Tall and clean-cut, Navalny has been a thorn in the side of the government since starting to campaign online against state corruption in 2007. He established himself as a powerful speaker at anti-Putin demonstrations that flared 16 months ago.

POTENTIAL RIVAL

The trial began on April 17 but was adjourned until Wednesday to give the defense more time to prepare.

Many Russians say political life in the former Soviet superpower is riddled with corruption and find it hard to believe Navalny is any better than the rest.

"I think it's more likely that he made some extra money for himself here, just stole it. I don't think it's political at all," said a housewife out walking with her baby in the center of Kirov, who gave her name only as Anya.

Marina, a 42-year-old construction engineer, said: "I think that overall it's political, to silence him. But nobody's free of sin these days so apparently there's something that the prosecution can work with to go after him."

Others are simply not interested in the fate of a man who has captured the imagination of urban youth and the emerging middle class in big cities but has failed to strike a chord with the millions of people who live in the provinces.

Navalny is rarely seen on state television, the main source of news for Russians outside major cities.

Since Putin's return to the Kremlin last May after four years as prime minister, two members of the dissident band Pussy Riot have been jailed, a prominent protest leader has been thrown out of parliament and another is under house arrest.

A dozen protesters also face sentences of up to 10 years over clashes with police at a rally on the eve of Putin's inauguration in May, and parliament has pushed through tough new penalties and fines for demonstrators who stray out of line.

(Reporting by Gabriela Baczynska, Writing by Timothy Heritage; editing by Elizabeth Piper and Alistair Lyon)

Source: http://news.yahoo.com/putin-foe-navalny-urges-russian-court-throw-charges-082054343.html

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Battling with bugs to prevent antibiotic resistance

Apr. 23, 2013 ? New scientific research published today in the journal PLoS Biology shows that bacteria can evolve resistance more quickly when stronger antibiotics are used.

Researchers from the University of Exeter and Kiel University in Germany treated E. coli with different combinations of antibiotics in laboratory experiments.

Unexpectedly they found that the rate of evolution of antibiotic resistance speeds up when potent treatments are given because resistant bacterial cells flourish most during the most aggressive therapies.

This happens because too potent a treatment eliminates the non-resistant cells, creating a lack of competition that allows resistant bacteria to multiply quickly. Those cells go on to create copies of resistance genes that help them rapidly reduce the effectiveness of the drugs. In tests this effect could even cause E.coli to grow fastest in the most aggressive antibiotic treatments.

In addition to evolution experiments, the results of this Engineering and Physical Sciences Research Council (EPSRC) and Medical Research Council (MRC) funded research were confirmed using mathematical models and whole-genome sequencing of resistant and non-resistant E. coli.

Professor Robert Beardmore, EPSRC Research Fellow from the University of Exeter said: "We were surprised by how quickly the bacteria evolved resistance. We nearly stopped the experiments because we didn't think some of the treatments should be losing potency that fast, sometimes within a day. But we now know that the bacteria remaining after the initial treatment have duplicated specific areas of their genome containing large numbers of resistance genes. These gene copies appear more quickly when the antibiotics are combined, resulting in the rapid evolution of very resistant bacteria.

"Designing new treatments to prevent antibiotic resistance is not easy, as this research shows, and governments may need to increase their funding for antibiotics research if scientists are to be able to keep pace with the rapid evolution of bacterial pathogens that cause disease."

Dr Rafael Pena-Miller from Biosciences at the University of Exeter said: "The evidence that combining antibiotics to make a more potent therapy can lead to the creation of more copies of the genes the bacteria needs to be resistant is of real concern."

Professor Hinrich Schulenberg from Kiel University in Germany said: "The interesting thing is that the bacteria don't just make copies of the genes they need. Just in case, they copy other genes as well, increasing resistance to antibiotics the cells weren't even treated with."

About 440 000 new cases of drug-resistant tuberculosis emerge annually, causing around 150 000 deaths. Statistics like this recently lead the Department of Health to state that antibiotic resistance poses one of the greatest threats to human health.

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The above story is reprinted from materials provided by University of Exeter, via EurekAlert!, a service of AAAS.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/zprA_T5Qf9w/130423172704.htm

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His Name Tells the Tale (Balloon Juice)

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Tuesday, April 23, 2013

Wildfires Prompt Colorado Insurance Changes - KKTV

DENVER (AP) -- Colorado lawmakers are close to agreement on a slate of insurance changes inspired by homeowners' complaints after last year's wildfires.

The state Senate gave final approval Monday to a bill aimed at making homeowner insurance easier to use. Changes include giving homeowners more time to file an inventory of the contents of their house after a total-loss claim for reimbursement.

The bill also requires homeowner insurance policies to be written more plainly, so customers understand their coverage.

The bill has already cleared the House, but in a slightly different forms. That means lawmakers will keep negotiating before the bill heads to the governor's desk.

Source: http://www.kktv.com/home/headlines/Wildfires-Prompt-Colorado-Insurance-Changes-204164611.html

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Corpse Party: Blood Drive heading to PS Vita | VG247

Tue, Apr 23, 2013 | 08:32 BST